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Modelling of ICAM-1 and LFA-1 interaction using Molecular Recognition Theory

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Polje Vrijednost
 
Relacija http://fulir.irb.hr/833/
http://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=44510
 
Naslov Modelling of ICAM-1 and LFA-1 interaction using Molecular Recognition Theory
 
Autor Štambuk, Nikola
Konjevoda, Paško
Vikić-Topić, Dražen
Pokrić, Biserka
 
Tema Chemistry
 
Opis The model of ICAM-1 and LFA-1 molecular interaction was used to test the application of the Molecular Recognition Theory for the identification of several discontinuous binding regions, i.e. ligand-receptor sites, within large antigenic molecules. Molecular Recognition Theory is an applicable heuristic algorithm for identification of possibly interacting amino acid pairs in short linear epitope/paratope sites within larger molecules. However, in order to achieve better efficiency this heuristic algorithm of molecular recognition has to be combined to several other procedures: molecular hydropathy analyses, secondary structure prediction methods and protein database search. The limitation of the combined MRT-hydropathy analyses is in the fact that it cannot explain 3D protein interactions, but it can be a valuable starting point for a more complex computational and experimental analysis.
 
Izdavač Croatian Chemical Society
 
Datum 2008-06
 
Vrsta resursa Article
PeerReviewed
 
Format (na primjer PDF) application/pdf
 
Jezik en
english
 
Prava
 
Identifikator http://fulir.irb.hr/833/1/CCA_81_2008_283_287_stambuk.pdf
Štambuk, Nikola and Konjevoda, Paško and Vikić-Topić, Dražen and Pokrić, Biserka (2008) Modelling of ICAM-1 and LFA-1 interaction using Molecular Recognition Theory Croatica Chemica Acta, 81 (2). pp. 283-287. ISSN 0011-1643